Home Chemistry Heterocyclic Building Blocks Benzisoxazoles Benzo[C]Isoxazole
Aromatic Substitution Reactions: The benzene ring in benzo[c]isoxazole is susceptible to electrophilic aromatic substitution reactions, such as nitration, halogenation, sulfonation, and Friedel-Crafts reactions. These reactions can modify the benzene ring by adding or substituting various functional groups.
Oxidation: Benzo[c]isoxazole can be oxidized under specific conditions to produce different products. Common oxidizing agents like potassium permanganate (KMnO4) or chromium (VI) oxide can be used for this purpose.
Reduction: Reduction reactions can be used to convert benzo[c]isoxazole into its reduced form. Common reducing agents like lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4) can be employed for this purpose.
Ring-Opening Reactions: Benzo[c]isoxazole can undergo ring-opening reactions under specific conditions, leading to the cleavage of the isoxazole ring.
Nucleophilic Addition: The oxygen atom in the isoxazole ring can act as a nucleophilic site, and reactions with electrophiles can lead to the addition of various functional groups.
Substitution Reactions: The isoxazole ring can undergo substitution reactions, particularly if it is activated by electron-donating or -withdrawing groups. Substitution reactions can occur at the nitrogen or carbon atoms of the isoxazole ring.
Rearrangements: Rearrangement reactions, such as the Beckmann rearrangement, can convert benzo[c]isoxazole into different isomeric forms with rearranged functional groups.
Cyclization Reactions: Benzo[c]isoxazole can participate in cyclization reactions, where it forms a ring with another functional group, leading to the synthesis of various heterocyclic compounds.
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